生命健康与安全学院(筹)

马丹军

时间:2023-09-08

姓名

马丹军

研究领域

创新药开发

联系方式

固定电话:

电子邮箱:djma@ipsnanjing.cn

招生信息

招生专业:生物化学、分子生物学、药学

招生方向:创新药制剂、药效、药理和药物分析

个人简介(教育背景、工作经历、社会兼职等)

马丹军,博士,2009年毕业于中国科学院上海生物化学与细胞生物学研究所,2009年赴美国进行博士后研究,先后工作于美国克瑞顿大学(Creighton University)医学中心,美国韦恩州立大学(Wayne State University)药学与健康科学学院,先后担任博士后,研究科学家,蛋白质组实验室主任。相关工作获得美国国立研究院、美国糖尿病协会、美国质谱协会、美国心脏病协会支持,总金额超过500万美金。主要研究方向为基于质谱的蛋白质组学、代谢组学、疾病标志物发现和药物筛选等方向。

目前承担课题情况(项目负责人)

中科南京生命健康高等研究院提供3年1000万元的科研启动经费,并根据期满执行情况,制定滚动支持计划。

学术成果(代表性论文、专利等)

发表文章:

1.Wang J, Wang X, Xie J, Yao B, Mo M,Ma D, Huang C, Xu R, Fu X, Tredget EE, Wu Y. Engineered Skin Substitute Regenerates the Skin with Hair Follicle Formation. Biomedicines. 2021 Apr 8;9(4):400. doi: 10.3390/biomedicines9040400.

2.Tan D, Zhao Y,Ma D,Tong F. Role of FSH and FSH receptor on HUVECs migration.Gene Ther.2020 Sep 29. doi: 10.1038/s41434-020-00195-w.

3.Xiao Q, Yu JS, Wang Y,Ma D,Zhou J, Lou X. 3-Difluoroalkyl Quaternary Oxindoles Inhibit Macrophage Pyroptosis by Blocking Inflammasome Recruitment of Caspase-1. ACS Med Chem Lett. 2020 Jun 12;11(7):1392-1401. doi: 10.1021/acsmedchemlett.0c00070.

4.Jiang H, Cao HJ, Ma N, Bao WD, Wang JJ, Chen TW, Zhang EB, Yuan YM, Ni QZ, Zhang FK, Ding XF, Zheng QW, Wang YK, Zhu M, Wang X, Feng J, Zhang XL, Cheng SQ,Ma DJ, Qiu L, Li JJ, Xie D.Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis.Proc Natl Acad Sci U S A. 2020 Mar 3;117(9):4770-4780.

5.Qi Y, Zhang X, Seyoum B, Msallaty Z, Mallisho A, Caruso M, Damacharla D,Ma D, Al-Janabi W, Tagett R, Alharbi M, Calme G, Mestareehi A, Draghici S, Abou-Samra A, Kowluru A, Yi Z.Kinome profiling reveals abnormal activity of kinases in skeletal muscle from adults with obesity and insulin resistance.The Journal of Clinical Endocrinology & Metabolism105 (3), dgz115.

6.S Li, SQ Huang, YX Zhao, YJ Ding,DJ Ma, QR Ding.Derivation and applications of human hepatocyte-like cells.World journal of stem cells11 (8), 535.

7.Zhao Y, Feng Z, Zhang Y, Sun Y, Chen Y, Liu X, Li S, Zhou T, Chen L, Wei Y,Ma D, Lui KO, Ying H, Chen Y, Ding Q.Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes.Cell Rep. 2019 Jan 22;26(4):884-892.e4. doi:10.1016/j.celrep.2018.12.100.

8.Tu C, Fiandalo MV, Pop E, Stocking JJ, Azabdaftari G, Li J, Wei H,Ma D, Qu J, Mohler JL, Tang L, Wu Y.Proteomic Analysis of Charcoal-Stripped Fetal Bovine Serum Reveals Changes in the Insulin-like Growth Factor Signaling Pathway.J Proteome Res.2018 Aug 3. doi:10.1021/acs.jproteome.8b00135. [Epub ahead of print]

9.Li S, Li M, Liu X, Yang Y, Wei Y, Chen Y, Qiu Y, Zhou T, Feng Z,Ma D, Fang J, Ying H, Wang H, Musunuru K, Shao Z, Zhao Y, Ding Q.Genetic and Chemical Screenings Identify HDAC3 as a Key Regulator in Hepatic Differentiation of Human Pluripotent Stem Cells.Stem Cell Reports.2018 May 24. pii: S2213-6711(18)30218-2. doi:10.1016/j.stemcr.2018.05.001. [Epub ahead of print]

10.Zhou Y, Gao J, Zhu H, Xu J, He H, Gu L, Wang H, Chen J,Ma D#, Zhou H#, Zheng J#.Enhancing Membrane Protein Identification Using a Simplified Centrifugation and Detergent-Based Membrane Extraction Approach.Anal Chem.2018 Feb 20;90(4):2434-2439.(#,co-corresponding)

11.Ma D*,#, Tu C*, Sheng Q*, Yang Y*, Kan Z, Guo Y, Shyr Y, Scott IC, Lou X#.Dynamics of Zebrafish Heart Regeneration Using an HPLC-ESI-MS/MS Approach.J Proteome Res.2018 Mar 2;17(3):1300-1308.(*, Equal Contribution; #,co-corresponding)

12.Xie X, Yi Z, Sinha S, Madan M, Bowen BP, Langlais P,Ma D, Mandarino L, Meyer C.Proteomics analyses of subcutaneous adipocytes reveal novel abnormalities in human insulin resistance.Obesity(Silver Spring). 2016 Jul;24(7):1506-14.

13.Zhang X, Damacharla D,Ma D, Qi Y, Tagett R, Draghici S, Kowluru A, Yi Z.Quantitative proteomics reveals novel protein interaction partners of PP2A catalytic subunit in pancreatic β-cells.Mol Cell Endocrinol.2016, 424:1-11.

14.Caruso M, Zhang X,Ma D, Yang Z, Qi Y, Yi Z.Novel Endogenous, Insulin-Stimulated Akt2 Protein Interaction Partners in L6 Myoblasts.PLoS One.2015, 10(10):e0140255.

15.Tu C, Sheng Q, Li J,Ma D, Shen X, Wang X, Shyr Y, Yi Z, Qu J.Optimization of Search Engines and Postprocessing Approaches to Maximize Peptide and Protein Identification for High-Resolution Mass Data.J Proteome Res.2015 Nov 6;14(11):4662-73.

16.Zhang X*,Ma D*, Caruso M, Lewis M, Qi Y, Yi Z.Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A.J Proteomics.2014 Sep 23;109:63-75.(*, Equal Contribution)

17.Caruso M*,Ma D*, Msallaty Z, Lewis M, Seyoum B, Al-janabi W, Diamond M, Abou-Samra AB, Højlund K, Tagett R, Draghici S, Zhang X, Horowitz JF, Yi Z.Increased interaction with insulin receptor substrate 1, a novel abnormality in insulin resistance and type 2 diabetes.Diabetes. 2014 Jun;63(6):1933-47.(*, Equal Contribution)

18.Papanicolaou A, Woo A, Brei B,Ma D, Masedunskas A, Gray E, Guishan Xiao G, Cho S, Brockhouse C.Novel aquatic silk genes Simulium (Psilozia) vittatum (Zett) Diptera: Simuliidae.Insect Biochem Mol Biol. 2013 Dec;43(12):1181-8.

19.Chen B, Yu M, Chang Q, Lu Y, Thakur C,Ma D, Yi Z, Chen F.Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin.Oncotarget. 2013 Sep;4(9):1427-37.

20.Wang J*, Zhang X,Ma D*, Lee WP, Xiao J, Zhao Y, Go VL, Wang Q, Yen Y, Recker R, Xiao GG.Inhibition of transketolase by oxythiamine altered dynamics of protein signals in pancreatic cancer cells.Exp Hematol Oncol.2013 Jul 27;2:18.(*, Equal Contribution)

21.Chen XW, Wang H, Bajaj K, Zhang P, Meng ZX,Ma D, Bai Y, Liu HH, Adams E, Baines A, Yu G, Sartor MA, Zhang B, Yi Z, Lin J, Young SG, Schekman R, Ginsburg D.SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion.Elife. 2013 Apr 9;2:e00444.

22.Ma D, Li Y, Hackfort B, Zhao Y, Xiao J, Swanson PC, Lappe J, Xiao P, Cullen D, Akhter M, Recker R, Xiao GG.Smoke-induced signal molecules in bone marrow cells from altered low-density lipoprotein receptor-related protein 5 mice.J Proteome Res.2012 Jul 6;11(7):3548-60.

23.Chao A, Zhang X,Ma D, Langlais P, Luo M, Mandarino LJ, Zingsheim M, Pham K, Dillon J, Yi Z.Site-specific phosphorylation of protein phosphatase 1 regulatory subunit 12A stimulated or suppressed by insulin.J Proteomics. 2012 Jun 18;75(11):3342-50.

24.Ma D*, Wang J*, Zhao Y, Lee WN, Xiao J, Go VL, Wang Q, Recker RR, Xiao GG. Inhibition of glycogen phosphorylation induces changes in cellular proteome and signaling pathways in MIA pancreatic cancer cells.Pancreas. 2012 Apr;41(3):397-408.(*, Equal Contribution)

25.Zhao Y, Deng C, Lu W, Xiao J,Ma D, Guo M, Recker RR, Gatalica Z, Wang Z, Xiao GG.let-7 microRNAs induce tamoxifen sensitivity by downregulation of estrogen receptor α signaling in breast cancer.Mol Med. 2011;17(11-12):1233-41.

26.Zhao Y, Cao R,Ma D, Zhang H, Lappe J, Recker RR, Xiao GG. Efficacy of calcium supplementation for human bone health by mass spectrometry profiling and cathepsin K measurement in plasma samples.J Bone Miner Metab. 2011 Sep;29(5):552-60.

27.Ma DJ, Li SJ, Wang LS, Dai J, Zhao SL, Zeng R.Temporal and spatial profiling of nuclei-associated proteins upon TNF-alpha/NF-kappaB signaling.Cell Res.2009 May;19(5):651-64.

28.Sheng QH, Wang LS, Dai J, Jiang XS, Li RX,Ma DJ, Li YX, Zeng R, Wu JR.Comparison of a proteomic approach with a microarray-based approach to detect exons in the mouse genome.Nat Genet.2006 Nov;38(11):1223-4.

29.Li C, Tan YX, Zhou H, Ding SJ, Li SJ,Ma DJ, Man XB, Hong Y, Zhang L, Li L, Xia QC, Wu JR, Wang HY, Zeng R.roteomic analysis of hepatitis B virus-associated hepatocellular carcinoma: Identification of potential tumor markers.Proteomics.2005 Mar;5(4):1125-39.

授权专利:

1.一种新型胰高血糖素类似物及其应用,ZL201910246124.0。

2.一种用于质谱的分段式碰撞装置,ZL202310559354.9。

3.一种干血斑中25-羟基维生素D的质谱检测试剂盒,ZL202221885574.8。

4.一种低温加样装置,ZL202221885910.9。

5.点血斑固定装置,ZL202221884674.9。

6.一种新型可装卸带刻度的96孔板,ZL202221884675.3。

7.多通道正压装置的可拆卸感应收集装置,ZL202221886225.8。

8.血清中维生素A萃取试剂盒,ZL202221978935.3。

出版图书:

蛋白质化学与蛋白质组学, 科学出版社, 2004。

国际会议邀请报告:

Danjun Ma, Xiangmin Zhang, Michael Caruso, Zhengping Yi. Regulation of Insulin on Tyrosine Phosphorylation in Human Skeletal. Diabetes. June 8-12, 2012. 72nd Scientific Sessions of American Diabetes Association. Philadelphia, Pennsylvania, USA.

获奖情况

2017年入选深圳市孔雀人才计划,获得深圳科创委国际合作项目支持;

2020年入选佛山市创新创业团队;

2021年入选中科院江西产业研究院创新创业团队;

2022年创新创业大赛佛山一等奖,广东省三等奖,国家优胜奖。

江苏省南京市江宁区天泉路188号

211135

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